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Dwight E. Clark, M.D.; James H. Rule, M.D.
JAMA. 1955;159(10):995-997. doi:10.1001/jama.1955.02960270015004.
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A uniformity of opinion as to whether radioiodine or surgery should be the preferred type of definitive therapy in any given case of hyperthyroidism would be almost impossible to obtain. Some individuals are still of the opinion that all cases of thyrotoxicosis should be treated by surgical means. Miller1 treats all cases of hyperthyroidism with radioiodine (I131) regardless of the patients' age or type of gland, with the exception of those cases in which the condition is associated with pregnancy or lactation. He emphasizes, however, that the wholesale treatment of children for thyrotoxicosis should not be carried out, and he is only administering the isotope to children, as part of a long-term study. Chapman and his co-workers2 have concluded that I131 should not be used in persons with either a single or multiple toxic nodular goiter, their reasons being the high incidence of carcinoma in clinically


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