We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Current Comment

JAMA. 1948;138(9):654. doi:10.1001/jama.1948.02900090028012.
Text Size: A A A
Published online


SARCOMAGENIC CELLOPHANE  In the course of experiments performed on rats to produce hypertension by wrapping cellophane film around one kidney, Oppenheimer1 and his associates of Columbia University noted that sarcomas developed in several rats in the neighborhood of the cellophane. The sarcomagenic properties of cellophane film were therefore tested on 110 adult male rats. In 55 of these the left kidney was loosely wrapped with "highstretch" cellulose sausage casing, according to the method introduced by Page.2 In the other 55 rats, a piece of cellophane 1 inch (2.5 cm.) square was embedded subcutaneously in the abdominal wall and kept in place by a surgical suture at each corner. Among the rats with the wrapped kidney, 23 survived over eleven months. Of these, 8, or 34.8 per cent, had large well defined tumors. Of the 55 rats in which the cellophane was embedded subcutaneously, 42 survived beyond eleven months.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.