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H. J. Anslinger
JAMA. 1948;138(8):609. doi:10.1001/jama.1948.02900080067020.
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To the Editor:—  There is evidence of increasing use by drug addicts of the new synthetic drug, methadon (6-dimethylamino-4,4-diphenyl-3-heptanone, also known by the trade names "dolophine" and "adanon") to gratify drug addiction. The result of a special observation of this trend in one district—which can be considered as substantially representative of the general trend in all districts—shows that most of these addicts are obtaining their supplies of "dolophine," for example, through narcotic "prescriptions" issued by registered practitioners. While this special observation related to use of the drug under the name "dolophine," the irregularities can be considered likewise incident to the use of methadon or "adanon," which are, of course, other names for the same drug.An investigating officer of this Bureau found that a large number of the addicts using methadon had previously confined their addiction to the use of morphine or heroin. He interviewed a number of these addicts


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