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Council on Pharmacy and Chemistry

JAMA. 1948;138(8):584-593. doi:10.1001/jama.1948.02900080042009.
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 The Effects of Streptomycin on Tuberculosis in Man, report to the Council on Pharmacy and Chemistry , J.A.M.A. 135:634-641 ( (Nov. 8) ) 1947
Link to Article[[XSLOpenURL/10.1001/jama.1947.02890100028007]]
The majority of these data were contributed by the following twenty-three hospitals. Fitzsimons General Hospital (USA), Denver; Corona Naval Hospital (USN), Corona, Calif., and Veterans Administration Hospitals at Brecksville, Ohio; Bronx, N. Y.; Butler, Pa.; Castle Point, N. Y.; Dayton, Ohio; Excelsior Springs, Mo.; Hines, Ill.; Legion, Texas; Livermore, Calif.; Memphis (Kennedy), Tenn.; Minneapolis; Oteen, N. C.; Richmond, Va.; Rutland Heights, Mass.; San Fernando, Calif.; Staten Island, N. Y.; Sunmount, N. Y.; Van Nuys, Calif.; Walla Walla, Wash.; Waukesha, Wis., and Wood, Wis. Data on a smaller number of cases were contributed by Veterans Administration Hospitals at Albuquerque, N. M.; Alexandria, La.; Bedford, Mass.; Chamblee, Ga.; Cleveland; Columbia, S. C.; Dearborn, Mich.; Fort Howard, Md.; Fort Logan, Colo.; Framingham, Mass.; Los Angeles; Louisville, Ky.; Martinsburg, W. Va.; McKinney, Texas; Nashville, Tenn.; Newington, Conn.; New Orleans; Oakland, Calif.; Outwood, Ky.; Springfield, Mo.; Temple, Texas; Wadsworth, Kan., and Whipple, Ariz., and by Nopeming Sanatorium, Nopeming, Minn., and Glen Lake Sanatorium, Oak Terrace, Minn.
 The Effect of Streptomycin upon Pulmonary Tuberculosis, Streptomycin Committee, Veterans Administration , Am. Rev. Tuberc. LVI: 485-605 ( (Dec.) ) 1947.
The results in 184 additional cases, from a single hospital, have been omitted because of differences in the method of study and reporting.
Dr. Howard M. Bosworth, Dr. William G. Childress, Dr. David A. Cooper, Dr. Bruce H. Douglas, Dr. H. Harold Fellows, Dr. John N. Hayes, Dr. Kirby S. Howlett Jr., Dr. Herbert L. Mantz, Dr. John H. Skawlem and Dr. Julius L. Wilson.
Brewer, L. A., III, and Bogen, E.;  Streptomycin in Tuberculous Tracheobronchitis , Am. Rev. Tuberc. LVI: 408-414 ( (Nov.) ) 1947.
Brock, B. L.:  Streptomycin in the Treatment of Draining Tuberculous Sinuses , J. A. M. A. 135:147-149 ( (Sept. 20) ) 1947.
Link to Article[[XSLOpenURL/10.1001/jama.1947.02890030015005]]
Bunn, P. A.:  One Hundred Cases of Miliary and Meningeal Tuberculosis Treated with Streptomycin , Am. J. M. Sc. , to be published.
Conducted on March 6 and 7, 1948, by Dr. Ralph K. Ghormley of the Mayo Clinic and Prof. Edward Evans of the University of Minnesota and their staffs.
Mason, E. E., and others:  Streptomycin in the Treatment of Tuberculous Enteritis , Am. J. M. Sc. , to be published.
Farrington, R. F.: Hull-Smith, H.; Bunn, P. A., and McDermott, W.:  Streptomycin Toxicity , J. A. M. A. 134:679-688 ( (June 21) ) 1947.
Link to Article[[XSLOpenURL/10.1001/jama.1947.02880250027007]]
This figure is rather arbitrarily selected as a criterion of resistance since it represents the average blood concentration from four to six hours after the intramuscular injection of 0.5 Gm. of streptomycin. since
Steenken, W., Jr.: Resistance: Minutes of the Fourth Streptomycin Conference , St. Louis, Veterans Administration, (May 1) , 2 and 3, 1947, pp. 52-56.
Feldman, W. H.; Karlson, A. G., and Hinshaw, H. C.:  Streptomycin Resistant Tubercle Bacilli: Effects of Resistance on Therapeutic Results in Tuberculous Guinea Pigs , Am. Rev. Tuberc. LVII: 162-174 ( (Feb.) ) 1948.
Figure 8 represents an attempt to indicate, graphically, the relative therapeutic effectiveness of streptomycin in various types of tuberculosis. The criteria selected for evaluation of effectiveness are mentioned in each instance, but it should be emphasized that any change in these criteria would decidedly alter both the height and the shading of the individual columns; thus, the acceptance of roentgenologic improvement instead of sputum conversion would increase the "pulmonary" column from 25 to 80 per cent and the inclusion of a post-treatment observation period would nearly double the height of the "bone and joint" column. Its information, therefore, is general rather than specific; its usefulness is qualitative rather than quantitative.


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