0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

SALICYLATE THERAPY IN RHEUMATIC FEVER

JAMA. 1948;138(5):367-368. doi:10.1001/jama.1948.02900050035014.
Text Size: A A A
Published online

To effect a cure of rheumatic fever, Coburn1 claims, one of two objectives must be realized. Either the immune response of the host must be modified so that the patient recovers promptly after his first attack or the capacity of the infected micro-organism to elaborate antigen must be inhibited by a chemotherapeutic agent. Since neither of these objectives has yet been realized, one is limited to the suppression of the inflammatory reaction. If salicylate therapy can modify the sterile inflammatory reaction which occurs during activity of the rheumatic process, one might expect this effect to inhibit the development of cardiac disease.

Evaluation of any form of therapy in rheumatic fever, Coburn states, is difficult because about 20 per cent of young adults may be expected to have a monocytic attack and recover spontaneously under symptomatic treatment. About 40 per cent of 43 young adults treated with daily doses of

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();