JAMA. 1948;138(5):357-362. doi:10.1001/jama.1948.62900050001008.
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CANCER OF THE KIDNEY  In two periods of life cancer of the kidney occurs, in infancy and in aging adult life. In infancy occurs one of the more frequent cancers of childhood, Wilms' tumor or infantile embryoma. This is a silent tumor and is highly malignant, with a serious and impressive record of fatal termination. More frequently, there occur in middle-aged or in elderly persons the various epithelial carcinomas of the kidney which are often silent until they reach considerable size and usually show their presence by blood in the urine. The early recognition of renal cancer in both these age groups is a problem for the medical practitioner, because by early surgical removal of the affected kidney lies the correction of an otherwise fatal course of the disease.Carcinoma of the kidney ranks third in frequency among the tumors of the urogenital system, following carcinoma of the bladder and


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