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Walter E. Shector; John T. McLaughlin, M.D.; Charles Dowling, M.D.
JAMA. 1955;158(12):1025-1026. doi:10.1001/jama.1955.02960120025007b.
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Methoxamine (Vasoxyl) hydrochloride is a synthetic sympathomimetic compound whose chief therapeutic use has been in the prevention of hypotension induced by spinal anesthesia. Recent reports in the literature, however, have suggested that methoxamine hydrochloride is effective in terminating attacks of supraventricular tachycardia. Chotkowski and co-workers have commented upon the dramatic reversion of the paroxysmal to the normal rhythm in a matter of seconds when the drug is administered intravenously, and Berger and Rackliffe state that methoxamine hydrochloride is perhaps unique among pressor amines in that it does not cause cardiac irritability. Stutzman and co-workers noted that, of some 26 sympathomimetic compounds tested, only methoxamine hydrochloride and phenylephrine (Neo-Synephrine) hydrochloride did not induce ventricular fibrillation in the experimental animal during cyclopropane anesthesia. Nathanson and Miller, however, noted ectopic ventricular activity after the administration of phenylephrine hydrochloride in a patient with shock following coronary occlusion, and, in a second patient with acute


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