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Harry F. Dowling, M.D.
JAMA. 1948;138(2):147. doi:10.1001/jama.1948.02900020043022.
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To the Editor:—  I have read with interest the letter from Dr. David Lehr which appeared in The Journal July 24, page 1150.Most of the apparent differences between Dr. Lehr's results and ours are due to different objectives and a difference in the methods used. We were attempting to determine whether a larger dose of sulfonamide compounds than is customarily used would lower the fatality rate in meningitis, and we employed the sulfadiazine-sulfamerazine combination in the hope that it would prevent the increase in renal calculi which might otherwise result from the increased dose, or better still, might lower the incidence of renal calculi in spite of the increased dose. Our paper reported the results obtained with this higher dose.We agree that it would be unfortunate if anyone should misconstrue our report to mean that, if similar doses of sulfonamide compounds were employed, the incidence of calculi would


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