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Joseph H. Lapin, M.D.; Josephine Tuason, M.D.
JAMA. 1955;158(6):472. doi:10.1001/jama.1955.02960060031008.
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The regional adenitis following vaccination with smallpox virus or with BCG is well known to the medical profession. Less well known is the regional adenitis following immunization with other antigens, such as pertussis vaccine, diphtheria toxoid, and tetanus toxoid. Glands in the axilla or groin, depending upon the site of injection, are almost invariably enlarged to the point of being easily palpable. However, we could find no report in the literature of large regional glands following such immunization. For this reason, two cases of marked axillary adenitis, due in all probability to the injection of antigens for immunization, are reported.


CASE 1.—The patient was injected with whooping cough vaccine at 5, 6, and 7 months of age, and at 8 months of age combined diphtheria-tetanus toxoid injections were given at monthly intervals. Three days after the first toxoid injection a mass approximately 2.0 by 2.5 cm. could


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