Henry I. Russek, M.D.
JAMA. 1955;158(3):216. doi:10.1001/jama.1955.02960030066020.
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To the Editor:—  In The Journal of April 9, 1955, page 1333, Dr. Robert C. Batterman has replied to my criticism of his conclusion that choline theophyllinate is an effective coronary casodilator drug. His opinion as to the efficacy of this preparation was based on a study of 32 patients with anginal syndrome in whom the criteria for effectiveness revolved about the need for glyceryl trinitrate therapy. My refusal to accept his interpretation of the findings was based on three main factors: 1. It is well known that "the pill the patient swallows, no matter what its nature, acquires potency as a symbol of faith, wisdom and support." The method of study employed by Batterman and associates apparently utilized no device to neutralize the elements of suggestion and bias and the factors responsible for spontaneous variations in the severity of the anginal state. 2. Even the demonstration of the superiority


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