So rapidly is biochemical knowledge accumulating that new editions of this textbook for medical students appear at three-year intervals. Thus, in the new edition, "large areas have been completely rewritten, notably those dealing with blood coagulation, enzymes and coenzymes, physiological oxidations, cholesterol metabolism, urea formation, transmethylation, and the mechanism of insulin action. There has been extensive revision of the sections... [on] the tricarboxylic acid cycle, coenzyme A, formation of gastric HCl, biochemistry of tumors, the role of vitamin A in vision, acid-base balance, and the metabolism of a number of amino acids. Pentose and fatty acid metabolism have been given more space, and the use of isotopes is reflected in many chapters. Among the new topics thought worthy of discussion are the dextrans, triiodothyronine, glucagon, serotonin, the carbonic anhydrase inhibitors, blood iodine, lipoic acid, and the structure of insulin and of oxytocin. A section is devoted to the nomenclature of