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Albert A. Bockman, M.D.
JAMA. 1955;157(13):1154. doi:10.1001/jama.1955.02950300082024.
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To the Editor:—  Daraprim (pyrimethamine) is a drug that is now used as an antimalarial. Its action is similar to that of the aminopterin class of folic acid antagonists. It has been subjected to a number of studies in animals and human beings. In the former it was found to lower the number of red and white blood cells in the peripheral circulation. Inconstant, minor lowering of the white blood cell counts in human beings has been noted but with no clinical consequence. Recently investigators have reported success in the treatment of polycythemia vera with this drug. Much of the latter work is as yet unpublished. Isaacs (J. A. M. A.156:1491 [Dec. 18] 1954) recently reported on the treatment of six cases without adverse effect with a dose as high as 50 mg. daily. The following case is reported because of the appearance of significant toxic manifestations. In


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