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Nathan M. Greenstein, M.D.
JAMA. 1955;157(13):1153. doi:10.1001/jama.1955.02950300081021.
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To the Editor:—  Several years ago a nasal decongestant was introduced under the name of Privine (2-naphthyl-methyl-imidazoline). While its local effects were satisfactory, it was found to produce a rather undesirable side-reaction (Waring, J. I.: J. A. M. A.129:129 [Sept. 8] 1945. Greenblatt, J.: J. Pediat.31:355, 1947). Small infants, particularly those under one year of age, would go off into a profound slumber, from which it was difficult to arouse them. While this soporific effect wore off in several hours, it caused a considerable degree of apprehension in the parents and also in the physicians who prescribed the medicament, for the latter were never certain which infant might develop this disturbing condition. Recently a new nasal decongestant has been introduced under the name of Tyzine (tetrahydroxoline hydrochloride) (Parish, F. A.: M. Times82:917, 1954). The 0.1% solution is available both as drops and in a


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