Sol Roy Rosenthal, M.D., Ph.D.
JAMA. 1955;157(10):801-807. doi:10.1001/jama.1955.02950270019006.
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In evaluating BCG vaccination, one must first define its potentialities. BCG vaccine, properly administered, will increase the resistance of both animal and man to virulent tubercle bacilli. This resistance is not absolute. The degree of resistance that it is possible to develop against tuberculosis may not be as great as for some other disease. Yet it should be borne in mind that there is no disease against which absolute immunity can be achieved. This fact was sharply brought into focus with the report of an epidemic of smallpox among our armed forces in Korea.1 This experience showed that adequate exposure could break down resistance even after multiple vaccinations against smallpox. The potency of the vaccine and the methods of administration were also taken into consideration. In evaluating BCG vaccination, all of these factors must be considered: (1) the vaccine itself, (2) the method of administration, and (3) the degree


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