JAMA. 1948;136(13):866-870. doi:10.1001/jama.1948.02890300016005.
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The object of this presentation is not to review the literature that has accumulated on the chemistry of the brain or to offer statistical evidence of what has been accomplished in this particular field of research, but it will attempt to indicate the needs and some of the indications that might stimulate young investigators to direct their talents into what may prove to be a fruitful sphere for concentrated efforts.

Probably every activity including thought manifested by any living organism is accompanied or represented by some form or forms of chemical reaction. Many of these reactions are already known in the behavior of metabolic patterns. The human organism is something of an energy-transforming system. It acquires energy from the sun, air, food and water, and probably from other sources as well. The result is behavior expressed in at least three different categories: (1) in chemical reactions at the metabolic and


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