0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

SICKLE CELL DISEASE WITH SEVERE HEMATURIA SIMULATING RENAL NEOPLASM

MARTIN S. ABEL, M.D.; CHESTER R. BROWN, M.D.
JAMA. 1948;136(9):624-625. doi:10.1001/jama.1948.72890260003008a.
Text Size: A A A
Published online

Since Herrick's first reported case,1 sickle cell disease has become a well described clinical and pathologic entity. The usual renal manifestations are of minor importance until late in the disease. Traces of albumin or urobilin or a few casts are found in the urine in some cases; in others the urine is essentially normal.2

The lesions in the kidneys, as elsewhere, stem from the fundamental tendency of the abnormally shaped erythrocytes to become blocked up in the small arterioles and capillaries. Early in the disease, renal sections exhibit vascular stasis and congestion. Later, after multiple small thromboses and infarctions, the kidneys show more or less extensive fibrosis with deposition of blood pigments.2e As more and more glomeruli are destroyed, renal function deteriorates and there may be terminal uremia.3

We could find only one report in the literature in which gross hematuria was a prominent feature of

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();