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TREATMENT OF CHRONIC EMPHYSEMA OF LUNGS WITH DIAMOX (CARBONIC ANHYDRASE INHIBITOR)

Charles L. Heiskell Jr., M.D.; Jay B. Belsky, M.D.; Benjamin F. Klaumann, M.D.
JAMA. 1954;156(11):1059-1063. doi:10.1001/jama.1954.02950110021008.
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Chronic emphysema of the lungs, particularly if associated with cardiac complications, has long posed a therapeutic problem. Treatment, until recently, has been limited to the supportive measures of bronchodilators, expectorants, antibiotics, oxygen, and the conventional management of cor pulmonale. The primary problems of defective alveolar ventilation, increased carbon dioxide content of the blood, and respiratory acidosis have remained unsolved.

One of the outstanding features of advanced emphysema of the lungs, particularly when it is complicated by congestive heart failure, is respiratory acidosis. This results from retention of carbon dioxide in the alveoli, consequent decrease in the alveolar blood diffusion gradient, and an increased carbon dioxide content of the blood. The ratio of carbonic acid to sodium bicarbonate, which determines the blood pH, is altered, and a reduction of blood pH ensues. In order to restore the normal carbonic acid-sodium bicarbonate ratio, the plasma bicarbonate level must be increased. This is

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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