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H. I. Teperson, M.D.
JAMA. 1950;144(8):707. doi:10.1001/jama.1950.02920080109024.
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To the Editor:—  The editorial on cancer detection tests which appeared in The Journal June 17, 1950, prompts me to give our experience with cancer tests conducted in a manner which apparently meets the criteria mentioned. Briefly, the tests used consist of (a) timing the coagulation of blood plasma by heat and (b) timing the reduction of methylene blue by plasma.In their original articles (Black, M. M.; Kleiner, I. S., and Bolker, H.: Changes in the Heat Coagulation of Plasma from Cancer Patients, Cancer Research8:2, 1948; Black, M. M.: Sulfhydryl Reduction of Methylene Blue with Reference to Alterations in Malignant Neoplastic Disease, ibid. 7:9, 1947; Plasma Reduction of Methylene Blue, Science108:540-541, 1948) the authors stated, "... combining the results of the dye reducing test and the coagulation studies, cancer was considered to be present with either or both and identified in 87 per cent of the


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