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H. I. Teperson, M.D.
JAMA. 1950;144(8):707. doi:10.1001/jama.1950.02920080109024.
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To the Editor:—  The editorial on cancer detection tests which appeared in The Journal June 17, 1950, prompts me to give our experience with cancer tests conducted in a manner which apparently meets the criteria mentioned. Briefly, the tests used consist of (a) timing the coagulation of blood plasma by heat and (b) timing the reduction of methylene blue by plasma.In their original articles (Black, M. M.; Kleiner, I. S., and Bolker, H.: Changes in the Heat Coagulation of Plasma from Cancer Patients, Cancer Research8:2, 1948; Black, M. M.: Sulfhydryl Reduction of Methylene Blue with Reference to Alterations in Malignant Neoplastic Disease, ibid. 7:9, 1947; Plasma Reduction of Methylene Blue, Science108:540-541, 1948) the authors stated, "... combining the results of the dye reducing test and the coagulation studies, cancer was considered to be present with either or both and identified in 87 per cent of the


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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