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October 21, 1950, Vol 144, No. 8 >
Other Articles | October 21, 1950

EXFOLIATIVE DERMATITIS AFTER UNDECYLENIC ACID THERAPY FOR PSORIASIS

BENCEL L. SCHIFF, M.D.
JAMA. 1950;144(8):620. doi:10.1001/jama.1950.62920080006006d.
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Perlman1 and Milberg2 reported good results from the use of undecylenic acid by mouth in the treatment of psoriasis and neurodermatitis. Perlman restated his belief in its value at the meeting of the American Academy of Dermatology and Syphilology in Chicago in December 1949. Among the side effects of the drug, exfoliative dermatitis was reported by Behrman.3 I had a similar case, herewith reported.

REPORT OF CASE  A white man aged 33 had mild psoriasis of the extensor surfaces of elbows and knees for the past seven years. His general health had always been good. With the exception of his psoriasis, his past history was noncontributory. On July 15, 1949 his family physician prescribed for him undecylenic acid. After the patient had taken nine capsules daily for two weeks, he began to feel nauseated and to vomit. He noticed red blotches on his face, chest and back.

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