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MONOCYTIC LEUKEMIA TREATED WITH PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH)

LAURANCE W. KINSELL, M.D.; HOBART ROGERS, M.D.; CHARLES BAKER, M.D.; BERT J. JENKINS, M.D.
JAMA. 1950;144(8):617-618. doi:10.1001/jama.1950.62920080003006b.
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Reports of the treatment of patients who have monocytic leukemia with pituitary adrenocorticotropic hormone (ACTH) or cortisone indicate a lack of favorable response or an actual acceleration of the progression of the disease.1 In this report we summarize the clinical and hematological data for a patient with acute monocytic leukemia who has shown impressive improvement during pituitary adrenocorticotropic hormone therapy.

REPORT OF CASE  A woman aged 56 years was examined by one of us (H. R.) in September 1949 because she had an acute respiratory infection. She gave a history of some previous fatigue and some loosening of the teeth. Examination of the blood disclosed 3,350,000 red blood cells, 9.2 Gm. hemoglobin and 6,100 white blood cells with 24 per cent neutrophils (11 per cent banded), 4 per cent eosinophils, 1 per cent basophils, 54 per cent "lymphocytes" and 16 per cent monocytes. The platelets were normal in appearance.

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