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J. Richard Durham, M.D.
JAMA. 1954;156(4):447-448. doi:10.1001/jama.1954.02950040153022.
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Dr. Master's letter was referred to Dr. Durham for comment, and his reply follows.-Ed.

To the Editor:—  I wish to answer Dr. Master's criticism of my recent article entitled "Negative Master Tests in the Prodromal Stage of Acute Myocardial Infarction" (J. A. M. A.135:826-827 [June 26] 1954). First, the ST depression in V4 was less than 1 mm.; actually, averaging the complexes in this lead resulted in a figure closer to 0.49 mm. If the criteria for positive tests are continually reduced by fractions of a millimeter in order to avoid the occurrence of a false negative test, the general applicability of the test is decreased and the number of false positive tests is, of course, increased. To argue over fractions of a millimeter in the graph as currently scaled is a reductio ad absurdum. Second, I should have stated that the single "two-step" test was


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