Dr. Master's letter was referred to Dr. Durham for comment, and his reply follows.-Ed.
To the Editor:—
I wish to answer Dr. Master's criticism of my recent article entitled "Negative Master Tests in the Prodromal Stage of Acute Myocardial Infarction" (J. A. M. A.135:826-827 [June 26] 1954). First, the ST depression in V4 was less than 1 mm.; actually, averaging the complexes in this lead resulted in a figure closer to 0.49 mm. If the criteria for positive tests are continually reduced by fractions of a millimeter in order to avoid the occurrence of a false negative test, the general applicability of the test is decreased and the number of false positive tests is, of course, increased. To argue over fractions of a millimeter in the graph as currently scaled is a reductio ad absurdum. Second, I should have stated that the single "two-step" test was