JAMA. 1954;155(16):1427. doi:10.1001/jama.1954.03690340049012.
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The rare syndrome called the male climacteric, which is defined in Dorland's Medical Dictionary as "the phenomena attending the normal decrease in sexual function in the male," is a much disputed term that has been the object of many claims and counterclaims. Briefly, the symptoms of the presumed entity include depression, irritability, loss of self confidence, sexual impotence, palpitation, lack of concentration, and weakness. A recent communication by Spence1 points out that the male climacteric exists as a definite clinical entity for the following reasons: (1) similar symptoms occasionally occur in postpubertal castrates and eunuchoids and are improved by androgen therapy; (2) the 17-ketosteroid secretion, while by no means diagnostic of testicular insufficiency, tends to be low; (3) some of the symptoms of the male climacteric can be explained by lack of the anabolic action of testosterone; (4) the urinary excretion of gonadotrophin is raised—indicative of testicular but not


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