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F. Brunn, M.D.
JAMA. 1950;143(17):1513-1514. doi:10.1001/jama.1950.02910520055023.
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To the Editor:—  In The Journal of May 20 (143:225, 1950) appeared an article by Dr. Louis A. Soloff entitled "Angina Pectoris During Decubitus" with the subheading "Hitherto Unrecognized Manifestation of Cardiac Failure." I should like to. comment on this article. In 1926 I advanced the theory that nocturnal shifts of blood and/or edema fluid play a role in the pathogenesis of cardiac asthma (nocturnal paroxysmal dyspnea) and that the seemingly miraculous results achieved through injection of posterior pituitary extract or an opiate are partly due to their effect of retaining fluid in the tissues (Med. Klin.22:1102 [July 16] 1926; Zentralbl. f. inn. Med.49:873 [Sept. 15] 1928). On the basis of these considerations I then attempted to prevent attacks of cardiac asthma by administration of mercurial diuretics with the intention of removing superfluous body water. Practical results were confirmed by all workers in this field,


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