0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

SERUM TEST FOR ACTIVE TUBERCULOSIS

JAMA. 1950;143(17):1489. doi:10.1001/jama.1950.02910520031013.
Text Size: A A A
Published online

Older serologic methods for the diagnosis of tuberculosis are unsatisfactory. Serums from patients with active tuberculosis often fail to react. Serums from normal persons often give positive reactions. These difficulties presumably arise from lack of a suitable reacting antigen. An improved antigen was therefore suggested by Middlebrook and Dubos,1 consisting of the water-soluble (rich in polysaccharide) fraction of mammalian tubercle bacilli adsorbed on sheep erythrocytes. Serums from tuberculous patients give specific hemagglutinations with these activated erythrocytes.

A modification of this antigen is currently proposed by Rothbard2 and associates of Montefiore Hospital, New York City. Instead of the "polysaccharide" extract of tubercle bacilli, they exposed sheep erythrocytes to more readily available, concentrated old tuberculin, which undoubtedly contains the polysaccharide fraction. To make the test, the patient's serum is heat inactivated and then freed from interfering antibodies by adsorption on normal sheep erythrocytes. In control tests with the resulting reduced

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();