0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

BRUCELLOSIS AND MULTIPLE SCLEROSIS

C. WESLEY EISELE, M.D.; NORMAN B. McCULLOUGH, M.D.; GRACE A. BEAL, Ph.D.
JAMA. 1950;143(17):1473-1474. doi:10.1001/jama.1950.02910520015006.
Text Size: A A A
Published online

A relation between brucellosis and multiple sclerosis has recently been postulated by Kyger and Haden.1 They reported a high incidence of cutaneous sensitivity to Brucella antigens in patients with the diagnosis of multiple sclerosis. In 118 patients, results of intradermal tests with killed Brucella organisms were reported as positive in 115. The possibility of multiple sclerosis being etiologically related to brucellosis was proposed largely on the basis of these findings. Widespread interest has been stimulated by this implied relation. In several instances which have come to our attention, patients with multiple sclerosis have been treated by methods believed to be useful in brucellosis. A further investigation of a possible relation between these two diseases seemed desirable.

MATERIAL AND METHODS 

Subjects.—  Fifty-two patients with the diagnosis of multiple sclerosis were studied for evidence of brucellosis or of previous exposure to Brucella. The diagnosis of multiple sclerosis had been established by

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

* * SCHEDULED MAINTENANCE * *

Our websites may be periodically unavailable between midnight and 04:00 ET Thursday, July 10th, for regularly scheduled maintenance.

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();