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RELATION OF BRUCELLOSIS AND MULTIPLE SCLEROSIS

CHARLES G. SPICKNALL, M.D.; LEONARD T. KURLAND, M.D.; B. N. CARLE, M.D.; LUTHER L. TERRY, M.D.
JAMA. 1950;143(17):1470-1473. doi:10.1001/jama.1950.02910520012005.
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The possible relation of brucellosis to multiple sclerosis was suggested by Kyger and Haden1 as the result of finding positive skin reactions to Brucella antigen in 115 of 118 patients with multiple sclerosis studied at the Cleveland Clinic. In view of the interest aroused by this report and the differences of opinion regarding interpretation of the findings, we decided to evaluate the brucellosis status of 20 multiple sclerosis patients from the Baltimore—Washington, D. C. area who were referred for study from clinics and hospitals or by private physicians.

The results of this study fail to support the findings of Kyger and Haden.1

METHODS  All patients were examined by a neurologist2 and were accepted for study if the criteria for diagnosis of multiple sclerosis as established by Kolb, Langworthy and Cakrtova3 were met. The patients were young or middle-aged adults, of whom 12 were white men, 7

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