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ENGLAND

JAMA. 1954;155(9):855-857. doi:10.1001/jama.1954.03690270051024.
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ABSTRACT

Penicillin.  —Two recent reports indicate the growing interest in penicillin for oral use, especially in children. Fairbrother and Daber (Lancet1:858, 1954) compare the insoluble benzathine penicillin (Penidural) with the soluble potassium penicillin G (Eskacillin) and the potassium salt of benzylpenicillin (Pradupen). A single dose of 300,000 to 600,000 units of benzathine penicillin was given to 181 patients (150 adults and 31 children). In adults, a dose of 300,000 units "gave disappointing results and was discontinued." With a dose of 600,000 units, a detectable serum penicillin level was found within three hours in 67 of 68 assays, and in six patients a level of 0.5 unit or more per milliliter was obtained. After five or six hours, 37 of 59 persons still had levels of 0.06 unit or more per milliliter. The results in children were more satisfactory. All had detectable serum-penicillin levels after a dose of 300,000 units;

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