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R. K. Ratliff, M.D.
JAMA. 1954;155(8):746. doi:10.1001/jama.1954.73690260010008f.
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The best known characteristic of hyaluronidase is its unique ability to disintegrate certain physiochemical barriers of the body. This function has been turned to practical purposes in the use of the drug as a spreading agent in hypodermoclysis, as a local anesthetic, and in the solution of many experimental problems. Recently in our hospital paraphimosis developed in a patient convalescing from a transurethral resection of the prostate gland. A shiny, tense, edematous ring and swelling of the ventral skin were noticed (see figure). Hyaluronidase, 150 turbidity units dissolved in 1 cc. of isotonic sodium chloride solution, was injected and dispersed into the edematous ring at the 3 o'clock and 9 o'clock positions. In 2 minutes the edema took on a pitting quality, and at the end of 12 minutes, when the second picture was taken, the swelling of both the ring and the frenum had completely disappeared and the prepuce


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