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SEVERE DRUG SENSITIVITY REACTION TO PHENINDIONE (PHENYLINDANDIONE)

Norman Makous, M.D.; Joseph B. Vander Veer, M.D.
JAMA. 1954;155(8):739-741. doi:10.1001/jama.1954.73690260003008a.
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In 1947, Soulier and Gueguen1 first reported the clinical use of phenindione (phenylindandione or Danilone) as an anticoagulant. Blaustein and others2 have had the widest reported experience with this drug. Except for the expected complication of minor bleeding, reports of untoward reactions have not appeared in the literature since the original paper was published in 1947. In our limited experience with 47 patients, there have been two cases of hematuria necessitating discontinuance of this anticoagulant and in a third case a severe toxic reaction due to phenindione sensitivity. The report of the latter case follows:

REPORT OF A CASE  A 42-year-old Negro woman was admitted to the Pennsylvania Hospital on May 8, 1953, with thrombophlebitis of the left leg. For one month swelling, stiffness, and popliteal tenderness had been present. The patient gave a history of menorrhagia and left lower abdominal discomfort for one year and had been

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