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JAMA. 1932;99(26):2160-2166. doi:10.1001/jama.1932.02740780012004.
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Cystine nephrolithiasis is a comparatively rare and exceedingly interesting pathologic finding. It probably occurs more often than is reported, as it is not at all unreasonable to suppose that some of the cases of recurrent renal calculi are of this type, as well as single instances of passed or surgically removed calculi not subjected to chemical analysis.

Simon,1 in 1900, collected from the literature 103 cases of cystine calculi. In 1912, Link2 collected 146 cases. In 1925, Seeger and Kearns3 noted 181 reported cases of cystinuria, 124 of which were complicated with calculus formation. Lewis4 found seventy-one reported cases of cystinuria from 1921 to 1932, although calculus formation was not observed in all of these. Henline,5 in 1930, reported three cases of cystine nephrolithiasis. About 70 per cent of the reported cases have been in males. The disease is quite widespread, cases having been reported


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