We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


J. H. COMROE Jr., M.D.; E. R. BAHNSON, M.D.; E. O. COATES Jr., M.D.
JAMA. 1950;143(12):1044-1048. doi:10.1001/jama.1950.02910470004002.
Text Size: A A A
Published online

Several reports have now appeared indicating that undesirable reactions may follow the administration of oxygen to patients with chronic anoxemia. Barach1 noted that patients with chronic anoxemia may become irrational, stuporous or comatose when given 50 to 100 per cent oxygen to breathe; in his experience their mental state returned to normal and none of the patients died even though inhalation of oxygen was continued. Godfrey, Pond and Wood2 studied an emphysematous patient who became deeply comatose within five minutes after the initiation of oxygen therapy (90 to 97 per cent) and regained consciousness with equal rapidity when the oxygen was removed. Davies and Mackinnon3 reported on 2 patients with cor pulmonale who showed neurologic changes during inhalation of oxygen. In the first there developed uncontrollable myoclonic movements of his arms, which disappeared when he breathed air; the second became comatose within two hours and died within


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.