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September 2, 1939, Vol 113, No. 10 >
Other Articles | September 2, 1939

THE EFFECT OF CERTAIN ANESTHETICS ON THE BLOOD

PAUL W. SEARLES, M.D.
JAMA. 1939;113(10):906-909. doi:10.1001/jama.1939.02800350016005.
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In the literature are numerous reports concerning the concentration and coagulation of the blood during ether anesthesia. Recently the concentration of blood in the course of anesthesia with sodium amytal has received considerable attention, but the results of these investigations have not been uniform. The observations for the most part have been made on clinical patients subjected not only to the anesthetic but to some operative procedure as well. It has been my purpose in this research to investigate the uncomplicated effect of ether anesthesia and sodium amytal anesthesia on the number of erythrocytes of the blood and to establish the uncomplicated effect of ether anesthesia on the coagulation time of the blood plasma.

The majority of the investigations concerning the effect of ether anesthesia on the number of circulating erythrocytes have shown an increase. Hamburger and Ewing1 found in the dog an increase of 15 per cent in

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