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PARATHYROID INSUFFICIENCY WITH SYMMETRICAL CEREBRAL CALCIFICATION:  REPORT OF THREE CASES, IN ONE OF WHICH THE PATIENT WAS TREATED WITH DIHYDROTACHYSTEROL

L. McKENDREE EATON, M.D.; SAMUEL F. HAINES, M.D.
JAMA. 1939;113(9):749-753. doi:10.1001/jama.1939.02800340019006.
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The roentgenographic finding of symmetrical cerebral calcification, particularly of the basal ganglions, is unusual, but the association of this condition with parathyroid insufficiency has been so frequent in our experience as to seem to justify this paper on the subject.

Symmetrical cerebral calcification (fig. 1) was first observed roentgenographically at the clinic in 1936. Since that time we have seen seven additional cases. The first six cases have been described elsewhere;1 the seventh is included in this report. So far as we are aware, the three cases about to be reported are the first in which the roentgenographic observation of symmetrical cerebral calcification has been associated with parathyroid insufficiency. In at least seven cases of parathyroid insufficiency the characteristic pathologic changes in the brain were found at necropsy. In all these cases the calcification was of sufficient degree to have been observed roentgenographically had such an examination been made.

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