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Daniel Sciarra, M.D.; Sidney Carter, M.D.; H. Houston Merritt, M.D.
JAMA. 1954;154(10):827-829. doi:10.1001/jama.1954.02940440025007.
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An appreciable number of patients with seizures are not helped by the standard anticonvulsants. There is, therefore, a constant search for new agents that will benefit this group. A new synthetic compound, primidone (Mysoline), has been made available to a number of investigators, and the results of four separate clinical trials had been reported at the time of writing.1 Handley and Stewart1a found this drug to be effective in 80% of 40 patients with grand mal seizures. In Butler's series1b of 58 patients with all types of seizures, there was improvement in 50% of patients with grand mal attacks. Smith and McNaughton1c were able to evaluate the results of primidone therapy in 61 patients and found that 35% were improved. Bonkalo and Arthurs1d reported on the use of primidone in the treatment of epileptic and nonepileptic psychiatric patients. They noted a reduction in the seizure


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