0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

HAZARDS OF LIVER EXTRACT AND FOLIC ACID IN LEUKEMIA

F. W. Ellis, M.D.
JAMA. 1954;154(8):702. doi:10.1001/jama.1954.02940420064024.
Text Size: A A A
Published online

ABSTRACT

To the Editor:—  Although our knowledge of the basic factors involved in the leukemic process and the relationship to nucleic acid metabolism is imperfect, there is ample evidence, both experimental and clinical, of the vital role of folic acid and vitamin B12 in normal hematopoiesis. Taking advantage of this fact, of course, has led to the clinical application of antimetabolites and, specifically, folic acid antagonists to therapy of the acute leukemias. Unnatural purines, such as 6-mercapto-purine, are also in use as blocking agents in the chain of nucleic acid synthesis for acute leukemia therapy. It seems irrational, therefore, to administer folic acid or liver to a patient with acute leukemia. The same contraindication to vitamin B12 seems probable, although there is conflicting evidence as to the specific role of this substance in nucleic acid metabolism of the leukocytic series. While this conclusion seems self-evident, there apparently is insufficient

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();