Arteriovenous fistulas may be present in Paget's disease of bone; the question remains whether they are the primary cause of this disease or merely secondary manifestations. We have done special studies of three patients who had osteitis deformans. In the first patient, arteriograms of the involved lower extremity were done. In the second patient, both arteriograms and special vascular studies, including determination of femoral venous pressure, studies of circulation with Evans blue (T-1824), and simultaneous measurement of the oxygen content of blood in both femoral veins, were done. Only the special vascular studies were done in the third patient.
The literature contains few reports of arteriograms in extremities of patients who had osteitis deformans. Reboul1 mentioned such a case, however, in which the lower extremity was involved. He stated, "One notices the considerable development of vascularity. All the arteries have a very large caliber. The collaterals are numerous."