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Ranald J. M. Steven, M.D.; Ralph M. Tovell, M.D.
JAMA. 1954;154(5):402-404. doi:10.1001/jama.1954.02940390026007.
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The time has come when the whole philosophy of the use of hexamethonium compounds must be thought out and expounded. Enough experience has been gained for us to define more clearly the circumstances under which they can be used, the contraindications to their use, what results may be reasonably expected of them, and the precautions that experience teaches us must be taken in their use. If some of these tenets have been neglected in the use of these compounds, that is no good reason for their abandonment for all except major operative procedures. It is our belief that in these compounds we possess agents with a wide range of usefulness that should not be brushed aside hastily. Far too little is known of their mode of action on the various systems of the body for them to be dismissed entirely as too dangerous for clinical use. Since the clinician has


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