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C. Wilmer Wirts, M.D.; Martin E. Rehfuss, M.D.; Herbert A. Yantes, M.D.
JAMA. 1954;154(1):36-39. doi:10.1001/jama.1954.02940350038009.
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The use of corticotropin in the treatment of idiopathic ulcerative colitis was first reported in 1950.1 Since that time a number of investigators have observed a favorable immediate response to this form of therapy, particularly when the disease was of the acute fulminating variety and of short duration.2 Our experience with the initial response of ulcerative colitis to corticotropin has been previously reported and corresponds closely to that of others.3 In the majority of patients a prompt defervescence, reduced number of liquid stools, better appetite, weight gain, correction of anemia, and greater emotional stability followed when this hormone was added to the usual supportive measures. An improvement in the proctoscopic and roentgen appearance of the colon regularly showed a lag in comparison to symptomatic improvement. The original group of patients now have all been followed for over two years. The course of these and additional patients who


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