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Earl D. Osborne, M.D.
JAMA. 1954;154(1):1-4. doi:10.1001/jama.1954.02940350003001.
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Statistical evaluation of results in the treatment of malignant cutaneous lesions is scientifically impossible. Except for superficial small epitheliomas on fairly smooth areas of glabrous skin, all lesions differ in some respect. In deciding the method of treatment in any particular case, the following factors must be considered: 1. The age and general condition of the patient, including the mental status. With many patients, it is desirable to treat the lesion when the patient is first seen. This is especially true when an emotional anxiety state caused by diagnosis of cancer exists. Elderly infirm patients are frequently unable to carry out a protracted schedule of treatment. 2. The accessibility of the patient to proper treatment. When he must travel long distances from home to office or clinic, two to seven trips a week are often impossible. If a one treatment method is available, with results comparable to any other method,


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