July 1, 1939, Vol 113, No. 1 >

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ANDROGENS AND THE "COLORING" OF WOMEN

E. C. Hamblen, M.D.; W. Kenneth Cuyler, M.S.

JAMA. 1939;113(1):38. doi:10.1001/jama.1939.72800260004011b.

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Dermatologic alterations are common in endocrine disease. Acne of adolescence and the hyperpigmentations of pregnancy are supposed to result from physiologic changes in the functions of the glands of internal secretion. Hamilton¹ and his group² have described characteristic alterations in the texture and pigmentation of the skin of surgically castrated and hypogonadal males following treatment with testosterone propionate. Hamilton and Hubert³ have related these pigmentational alterations to a "developing" action of the androgens on relatively colorless material laid down in the skin as the result of exposure.

In view of this apparent role of androgens in "developing" melanin, our observations on the urinary titers of androgens in normal white women seem significant when their "complexions" are considered. The average daily androgenic titers of true blondes have been found to be distinctly lower than those of marked brunettes.

Employing a colorimetric method for the determination of urinary

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Hamblen EC, Cuyler W. ANDROGENS AND THE "COLORING" OF WOMEN. JAMA. 1939;113(1):38. doi:10.1001/jama.1939.72800260004011b.

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