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July 1, 1939, Vol 113, No. 1 >
Other Articles | July 1, 1939

THE USE OF HEPARIN IN BLOOD TRANSFUSIONS

S. W. SAPPINGTON, M.D.
JAMA. 1939;113(1):22-25. doi:10.1001/jama.1939.02800260024006.
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Heparin as a natural anticoagulant has frequently been suggested for use in blood transfusions, but the difficulty in obtaining a pure and potent product free from toxic effects, as well as the high cost of production, has been a hindrance to its trial and use. Mason1 in 1924 reported some experiments on thirty-three human subjects relative to the use of heparin in blood transfusions, but his product was too toxic for routine clinical purposes. Howell2 in 1928 obtained a purified heparin which was tried out in transfusions on ten patients, apparently with good results, though subsequent reports of its use are wanting. In 1933 Schmitz and Fischer3 in Copenhagen and Charles and Scott4 in Toronto obtained heparin in a pure state. Jorpes5 showed that this pure heparin is a mucoitin polysulfuric ester. It is now being produced commercially and stable, potent preparations, apparently nontoxic, are

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