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J. M. Ruffin, M.D.; E. C. Texter Jr., M.D.; D. D. Carter, M.D.; G. J. Baylin, M.D.
JAMA. 1953;153(13):1159-1161. doi:10.1001/jama.1953.02940300017005.
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The anticholinergic drugs are compounds that have been introduced recently into clinical medicine. As with other new agents that have been employed in the past in the treatment of peptic ulcer, the initial reports of the value of these drugs were glowing with enthusiasm. It was stated that one of these compounds, methantheline (Banthine), was so effective as the sole treatment of ulcer that conventional medical management was no longer necessary, that recurrences could be prevented, and that the need for surgery was obviated.1 Many of these studies, however, were not controlled, and it is difficult to determine whether the beneficial effects attributed to the drug were actually produced by it. Recent investigations, more critically conducted, have failed to confirm some of the original observations, and, as a result, considerable confusion exists in the profession as to the exact value of these agents. The purpose of this paper is


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