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JAMA. 1946;132(6):329-330. doi:10.1001/jama.1946.02870410017006.
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The purpose of this paper is to call attention to a new method of preparing gelatin dipped in topical thrombin, which is utilized for the control of troublesome venous oozing in neurosurgery. Ligature, coagulation and the application of metallic clips are often of no avail, because of the inaccessibility or retraction of the severed vessel.

The application of crushed muscle has been effective because of adhesion to the bleeding surface and the potential release of thrombin. However, this has not been too practical since the muscle pledget can easily be moved from the site of hemorrhage.

Mechanical packing of a wound or the application of hot sponges in a delicate soft tissue such as that of the brain, spinal cord or nerves may be attended with a disruption of physiologic response and with distress to the patient after the operation.

Thus the work of Ingraham and Bailey was hailed with


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