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Clinical Notes, Suggestions and New Instruments

JAMA. 1946;132(5):281-283. doi:10.1001/jama.1946.02870400029006.
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Probable Herxheimer Reactions  HAROLD A. TUCKER, M.D. and RAYMOND C. V. ROBINSON, M.D. BaltimoreThe penicillin treatment of syphilis is no longer entirely an inpatient experimental procedure. The practicing physician will be treating more and more patients with symptomatic and asymptomatic neurosyphilis. Two recent Herxheimer-like reactions of a neurologic character occurring in patients undergoing penicillin treatment of neurosyphilis at the Johns Hopkins Hospital were of such alarming proportions that it is thought wise to report them in some detail.


Case 1.—  A white woman aged 32, a housewife, was admitted to the ward on Aug. 1, 1945, because of aphasia and rightsided hemiparesis of two days' duration. She had been aphasic on two occasions within the previous ten months, but both times she had


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