JAMA. 1946;132(5):272-278. doi:10.1001/jama.1946.02870400020004.
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Penicillin spray, as used in this report, is produced by a hand-operated bulb atomizer and is utilized by inhalation. The patient holds his breath at the end of the inspiration, allowing the suspended penicillin to settle on the infected mucous membranes. The terms aerosol penicillin and penicillin spray are used synonymously. An aerosol is a fine suspension of a liquid or solid in a gaseous medium.

Penicillin is perhaps the greatest life-saving drug today. The greatest drawback to its general use by the country practitioner especially, and to a lesser degree by his urban brother, in this day of overcrowded hospitals and scarcity of nurses is that its use by the accepted intramuscular or intravenous routes requires either hospitalization or the employment of two trained nurses. The use of a hand atomizer to produce a spray of penicillin, which is inhaled to medicate infections of the respiratory tract, removes the


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