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JAMA. 1946;132(2):80-81. doi:10.1001/jama.1946.02870370026009.
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Chronic progressive exophthalmos in thyrotoxicosis is a highly complex phenomenon; its etiology has not been completely elucidated. This exophthalmos may show considerable variation from day to day in its early stages and may disappear after death or under general anesthesia. The degenerative and inflammatory changes in the orbital contents are no doubt the result rather than the cause of the exophthalmos. The etiologic role of extracts of the anterior pituitary lobe in the production of exophthalmos was demonstrated by Schockaert in 1931 and by Loeb and his associates in 1932 working with young guinea pigs. Marine1 produced exophthalmos and large parenchymatous goiters in puberal rabbits by daily intramuscular injection of methyl cyanide. The exophthalmos was even more easily and quickly produced when the thyroid was previously removed. Smelser2 found that injection of anterior pituitary extract into guinea pigs for from three to nine weeks resulted in loss of


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