The use of cortin as a therapeutic measure is still in the experimental stage. Sufficient data have been gathered by various observers to indicate its efficiency in ameliorating the symptoms and altering the course of many cases of Addison's disease. This malady represents the only condition in which cortical insufficiency has been proved definitely.
The use of cortin in Addison's disease has not been so successful as the use of insulin in diabetes, and perhaps this is due to inadequate dosage. There may be other factors in the etiology of the Addison's syndrome. In the present paper, we are giving further experiences in the treatment of Addison's disease and in the use of cortin in other clinical conditions. There are undoubtedly other conditions in which cortical insufficiency exists, but as there are no real criteria of such inadequacy, one can only try the effect of cortin in cases in which