April 29, 1939, Vol 112, No. 17 >

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PURPURA HAEMORRHAGICA FOLLOWING USE OF SEDORMID: TWO ATTACKS IN ONE PERSON

Teresa McGovern, M.D.; Irving Wright, M.D.

JAMA. 1939;112(17):1687-1688. doi:10.1001/jama.1939.62800170001011.

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ABSTRACT

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Cases of purpura haemorrhagica after the use of sedormid (allyl-isopropyl-acetyl-carbamide) have been reported with increasing frequency since 1933. Joekes¹ reviewed the literature on this subject and stated that there were to date thirty-seven reported cases of purpura haemorrhagica due to sedormid. Since the period covered by his recent survey, seven more cases have been added to the literature.² It is interesting to note that on March 5, 1938, the Council on Pharmacy and Chemistry of the American Medical Association³ declared sedormid not acceptable for New and Nonofficial Remedies. Also of the twenty recorded observers, only four are Americans.⁴ In view of this we feel that it might be pertinent to describe a recent case of severe purpura haemorrhagica with two separate episodes due to this sedative.

REPORT OF CASE A white woman aged 57 complained of multiple subcutaneous hemorrhages, which she had noticed on finishing her

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McGovern T, Wright I. PURPURA HAEMORRHAGICA FOLLOWING USE OF SEDORMID: TWO ATTACKS IN ONE PERSON. JAMA. 1939;112(17):1687-1688. doi:10.1001/jama.1939.62800170001011.

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