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Perrin H. Long, M.D.
JAMA. 1950;142(1):49-50. doi:10.1001/jama.1950.02910190051018.
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To the Editor:—  A short current comment appeared in The Journal (141:924 [Nov. 26] 1949) dealing with the relation of antibiotics to the coagulation of the blood. It stated that the authors of at least one of the three cited papers had expressed the belief that "the definite shortening of the clotting time at the height of antibiotic therapy is of practical clinical interest."I agree that such a decrease in the clotting time would be of practical clinical interest if it were supported by controlled and statistically reliable data. I would like to point out an extraordinary but nevertheless highly important turn that this subject has taken. In the New York Times of Oct. 12, 1949, John N. Popham, in his report of the third session of the Thirteenth Congress of the International Society of Surgery, cites Dr. Alton Ochsner as saying, "The increased incidence of thrombo-embolism and


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