Let us first admit two obvious facts: the physician depends on pharmaceutical manufacturers to produce useful and dependable drugs, and the manufacturers depend on physicians to prescribe and use drugs Whenever a therapeutic advantage may be anticipated. Implicit in these statements is a surprising variety of topics for discussion.
Let us turn back to the year 1724. I choose this date because it appears on the title page of a small volume I cherish, entitled "Mr. Boyle's Receipts." The same John Boyle, whose statement of the interrelationship between pressure and volume of gases is the familiar Boyle's Law, was a therapeutically minded chemist. He assembled numerous directions for preparing remedies and then solicited trials of their efficacy by the physicians of his day. Remedies that gained sufficient approval were published in the volume referred to above. Following are a few examples of what the physician could expect from his local